Classes of non-Hermitian operators that have only real eigenvalues are presented.Such operators appear in quantum mechanics and are expressed in terms of the generators of the Weyl-Heisenberg algebra.For each non-Hermitian operator A, a Hermitian involutive operator Ĵ such that A is Ĵ-Hermitian, that is, ĴA = A * Ĵ, is found.Moreover, we construct a positive definite Hermitian Q such that A is Q-Hermitian, allowing for the standard probabilistic interpretation of quantum mechanics.Finally, it is shown that the considered matrices are similar to Hermitian matrices.