A fire in a clean room may cause a serious loss by spreading smoke particles. The effects of the width of smoke curtains on delay in smoke spread, which is located the work area boundaries, were investigated by using a computational fluid dynamics, for loss prevention by smoke spreading from one fire area to another. The fire scenario was set to a 1 MW methanol fire in a space of floor and 4 m high. Distributions of temperature and smoke particles were compared for the width of the smoke curtains 0 (without smoke curtains), 1, 2, 3m. It was confirmed that a larger width of the smoke curtain delays spread of smoke more, and that making the work areas compartments is necessary to confine the smoke in the fire area.