LGR5型
生物
干细胞
癌症干细胞
细胞生物学
Wnt信号通路
再生(生物学)
成体干细胞
干细胞标记物
细胞分化
癌症研究
信号转导
遗传学
基因
作者
Carly Leung,Si Hui Tan,Nick Barker
标识
DOI:10.1016/j.tcb.2018.01.010
摘要
The discovery of leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5) as both a marker of adult stem cells and a critical modulator of their activity via its role as an effector of Wnt/R-spondin (Rspo) signaling has driven major advances in our understanding of stem cell biology during homeostasis, regeneration, and disease. Exciting new mouse and organoid culture models developed to study the endogenous behavior of Lgr5-expressing cells in health and disease settings have revealed the existence of facultative stem cell populations responsible for tissue regeneration, cancer stem cells (CSCs) driving metastasis in the gut, and Lgr5+ niche cells in the lung. Here we review these recent advances and discuss their impact on efforts to harness the therapeutic potential of adult stem cells and their cancer counterparts in the clinic.
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