癌症干细胞
干细胞
癌症研究
生物
癌细胞
癌症
细胞分化
干细胞标记物
转移
细胞生物学
遗传学
基因
作者
Xiong Jin,Xun Jin,Hyunggee Kim
出处
期刊:Tumor Biology
[SAGE]
日期:2017-10-01
卷期号:39 (10): 101042831772993-101042831772993
被引量:74
标识
DOI:10.1177/1010428317729933
摘要
Cancer stem cells can generate tumors from only a small number of cells, whereas differentiated cancer cells cannot. The prominent feature of cancer stem cells is its ability to self-renew and differentiate into multiple types of cancer cells. Cancer stem cells have several distinct tumorigenic abilities, including stem cell signal transduction, tumorigenicity, metastasis, and resistance to anticancer drugs, which are regulated by genetic or epigenetic changes. Like normal adult stem cells involved in various developmental processes and tissue homeostasis, cancer stem cells maintain their self-renewal capacity by activating multiple stem cell signaling pathways and inhibiting differentiation signaling pathways during cancer initiation and progression. Recently, many studies have focused on targeting cancer stem cells to eradicate malignancies by regulating stem cell signaling pathways, and products of some of these strategies are in preclinical and clinical trials. In this review, we describe the crucial features of cancer stem cells related to tumor relapse and drug resistance, as well as the new therapeutic strategy to target cancer stem cells named "differentiation therapy."
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