Single values of serum transferrin receptor and transferrin receptor ferritin index can be used to detect true and functional iron deficiency in rheumatoid arthritis patients with anemia

Arthritis & RheumatismVolume 43, Issue 5 p. 1016-1020 Clinical ScienceFree to Read Single values of serum transferrin receptor and transferrin receptor ferritin index can be used to detect true and functional iron deficiency in rheumatoid arthritis patients with anemia Pauli Suominen, Corresponding Author Pauli Suominen Turku University Central Hospital, Turku, FinlandCentral Laboratory, Turku University Central Hospital, PO Box 52, FIN-20521, Turku, FinlandSearch for more papers by this authorTimo Möttönen, Timo Möttönen Turku University Central Hospital, Turku, FinlandSearch for more papers by this authorAllan Rajamäki, Allan Rajamäki Turku University Central Hospital, Turku, FinlandSearch for more papers by this authorKerttu Irjala, Kerttu Irjala Turku University Central Hospital, Turku, FinlandSearch for more papers by this author Pauli Suominen, Corresponding Author Pauli Suominen Turku University Central Hospital, Turku, FinlandCentral Laboratory, Turku University Central Hospital, PO Box 52, FIN-20521, Turku, FinlandSearch for more papers by this authorTimo Möttönen, Timo Möttönen Turku University Central Hospital, Turku, FinlandSearch for more papers by this authorAllan Rajamäki, Allan Rajamäki Turku University Central Hospital, Turku, FinlandSearch for more papers by this authorKerttu Irjala, Kerttu Irjala Turku University Central Hospital, Turku, FinlandSearch for more papers by this author First published: 02 April 2001 https://doi.org/10.1002/1529-0131(200005)43:5<1016::AID-ANR9>3.0.CO;2-3Citations: 61AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Objective To elucidate the use of serum transferrin receptor (sTfR) to distinguish between iron-deficiency anemia (IDA) and anemia of chronic disease (ACD), and to establish an improved scheme to identify functional iron deficiency (FID) in rheumatoid arthritis (RA) patients with anemia. Methods We studied 30 anemic RA patients whose iron status was confirmed by bone marrow examination and determination of the sTfR level, serum ferritin level, and sTfR–log ferritin index (TfR–F Index). All patients with diminished or exhausted iron stores (n = 18) received oral iron supplementation. Results Baseline values of sTfR and the TfR–F Index predicted the response correctly in all patients who received supplementation treatment and were normal in 10 of 11 patients with normal initial iron stores (ACD). Conclusion The results of this study elucidate the roles of sTfR and the TfR–F Index in the differential diagnosis between IDA and ACD and provide direct evidence that these parameters are useful in detecting FID, irrespective of the concurrent iron storage status. Citing Literature Volume43, Issue5May 2000Pages 1016-1020 RelatedInformation