Dimensionality reduction boosts the peroxidase-like activity of bimetallic MOFs for enhanced multidrug-resistant bacteria eradication

The antibacterial strategy using cutting-edge metal-organic framework (MOF)-based nanozymes can effectively solve the problem caused by antibiotic resistance to protect human health and the environment; however it has been significantly limited by the complicated modification method and non-ideal catalytic activity. Herein, we report a facile dimensionality-reduction strategy to improve the catalytic activity of MOF-based nanozymes. By reducing the dimensionality of two-dimensional Co-TCPP(Fe) (Co-Fe NSs) to zero-dimensional Co-TCPP(Fe) (Co-Fe NDs), the peroxidase-like activity of the prepared bimetallic Co-Fe NDs was almost tripled. Consequently, the bimetallic Co-Fe NDs can highly efficiently catalyze the lower-concentration H₂O₂ into reactive oxygen species (ROS), resulting in a favorable antibacterial effect against methicillin-resistant Staphylococcus aureus (MRSA). Meanwhile, Co-Fe NDs can effectively promote wound healing and water environment disinfection with good biocompatibility. This work reveals the potential of a zero-dimensional bimetallic MOF-based nanozyme in resisting drug-resistant bacteria and holds great promise for future clinical and environmental applications.