冈崎碎片
生物
遗传学
计算生物学
功能(生物学)
DNA
细胞生物学
DNA复制
真核细胞DNA复制
作者
Lingzi Ma,Haitao Sun,Tharindumala Abeywardana,Li Zheng,Binghui Shen
标识
DOI:10.1016/j.tig.2022.04.001
摘要
Proper function of structure-specific nucleases is key for faithful Okazaki fragment maturation (OFM) process completion. Deregulation of such nucleases leads to aberrant OFM and causes a spectrum of mutations, some of which may confer survival outcomes under specific stresses and serve as attractive targets for therapeutic intervention in human cancers.
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