失调
肠道菌群
免疫系统
免疫学
疾病
发病机制
生物
粪便细菌疗法
微生物群
炎症
免疫失调
肠-脑轴
医学
生物信息学
微生物学
艰难梭菌
病理
抗生素
作者
Kaijian Hou,Zhuo‐Xun Wu,Xuan‐Yu Chen,Jingquan Wang,Dongya Zhang,Chuanxing Xiao,Dan Zhu,Jagadish Koya,Liuya Wei,Jilin Li,Zhe‐Sheng Chen
标识
DOI:10.1038/s41392-022-00974-4
摘要
The role of microbiota in health and diseases is being highlighted by numerous studies since its discovery. Depending on the localized regions, microbiota can be classified into gut, oral, respiratory, and skin microbiota. The microbial communities are in symbiosis with the host, contributing to homeostasis and regulating immune function. However, microbiota dysbiosis can lead to dysregulation of bodily functions and diseases including cardiovascular diseases (CVDs), cancers, respiratory diseases, etc. In this review, we discuss the current knowledge of how microbiota links to host health or pathogenesis. We first summarize the research of microbiota in healthy conditions, including the gut-brain axis, colonization resistance and immune modulation. Then, we highlight the pathogenesis of microbiota dysbiosis in disease development and progression, primarily associated with dysregulation of community composition, modulation of host immune response, and induction of chronic inflammation. Finally, we introduce the clinical approaches that utilize microbiota for disease treatment, such as microbiota modulation and fecal microbial transplantation.
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