优势比
全国健康与营养检查调查
镉
医学
置信区间
Mercury(编程语言)
泌尿系统
尿
逻辑回归
勃起功能障碍
内科学
风险因素
人口
生理学
环境卫生
化学
有机化学
计算机科学
程序设计语言
作者
Chunhui Liu,Weipu Mao,Zonghao You,Bin Xu,Shuqiu Chen,Jianping Wu,Chao Sun,Ming Chen
标识
DOI:10.1007/s11356-022-20910-x
摘要
Heavy metals are ubiquitous and nonbiodegradable pollutants that are widely distributed in the environment. Heavy metal exposure can damage various biological tissues and cause several diseases. This study aimed to investigate the association between blood and urinary cadmium, lead, and mercury levels and erectile dysfunction (ED) based on data from the 2001-2004 National Health and Nutrition Examination Survey. In total, 3681 participants were included in the analysis. Results showed that participants with ED had high blood cadmium, mercury, creatinine, urinary lead, cadmium levels, low blood lead, serum cotinine, and urinary mercury levels. Multivariate logistic regression analysis showed that only blood cadmium level was an independent risk factor of ED (tertile [T]2 vs T1: odds ratio = 1.495, 95% confidence interval: 1.181-1.892, p = 0.001; T3 vs T1: odds ratio = 2.089, 95% confidence interval: 1.554-2.809, p < 0.001). The dose-response curve showed a positive nonlinear association between blood cadmium and lead levels and ED and a negative nonlinear association between blood and urinary mercury levels and ED after propensity score matching. In conclusion, heavy metal exposure is closely correlated with the development of ED, and a high blood cadmium level is an independent risk factor of ED.
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