医学
列线图
接收机工作特性
磁共振成像
放射科
胰腺导管腺癌
置信区间
转移
回顾性队列研究
曲线下面积
核医学
肿瘤科
内科学
胰腺癌
癌症
作者
Zhang Shi,Cheng-Le Ma,Xin Huang,Dairong Cao
摘要
Background Determining the absence or presence of peripancreatic lymph nodal metastasis (PLNM) is important to the pathologic staging, prognostication, and guidance of treatment in pancreatic ductal adenocarcinoma (PDAC) patients. Computed tomography and MRI had a poor sensitivity and diagnostic accuracy in the assessment of PLNM. Purposes To develop and validate a 3 T MRI primary tumor radiomics‐based nomogram from multicenter datasets for pretreatment prediction of the PLNM in PDAC patients. Study Type Retrospective. Subjects A total of 251 patients (156 men and 95 women; mean age, 60.85 ± 8.23 years) with histologically confirmed pancreatic ductal adenocarcinoma from three hospitals. Field Strength and Sequences A 3.0 T and fat‐suppressed T1‐weighted imaging. Assessment Quantitative imaging features were extracted from fat‐suppressed T1‐weighted (FS T1WI) images at the arterial phase. Statistical Tests Normally distributed data were compared by using t ‐tests, while the Mann–Whitney U test was used to evaluate non‐normally distributed data. The diagnostic performances of the preoperative and postoperative nomograms were assessed in the external validation cohort with the area under receiver operating characteristics curve (AUC), calibration curve, and decision curve analysis (DCA). AUCs were compared with the De Long test. A p value below 0.05 was considered to be statistically significant. Results The AUCs of magnetic resonance imaging (MRI) Rad‐score were 0.868 (95% confidence level [CI]: 0.613–0.852) and 0.772 (95% CI: 0.659–0.879) in the training and internal validation cohort, respectively. The preoperative and postoperative nomograms could accurately predict PLNM in the training cohort (AUC = 0.909 and 0.851) and were validated in both the internal and external cohorts (AUC = 0.835 and 0.805, 0.808 and 0.733, respectively). DCA indicated that the two novel nomograms are of similar clinical usefulness. Data Conclusion Pre−/postoperative nomograms and the constructed radiomics signature from primary tumor based on FS T1WI of arterial phase could serve as a potential tool to predict PLNM in patients with PDAC. Evidence Level 3 Technical Efficacy Stage 2
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