基质金属蛋白酶
细胞外基质
形态发生
动脉粥样硬化
伤口愈合
细胞生物学
病理
基质(化学分析)
癌症研究
化学
生物
功能(生物学)
医学
免疫学
内科学
生物化学
基因
色谱法
作者
Hideaki Nagase,Robert Visse,Gillian Murphy
出处
期刊:Cardiovascular Research
[Oxford University Press]
日期:2006-02-15
卷期号:69 (3): 562-573
被引量:2819
标识
DOI:10.1016/j.cardiores.2005.12.002
摘要
Matrix metalloproteinases (MMPs), also called matrixins, function in the extracellular environment of cells and degrade both matrix and non-matrix proteins. They play central roles in morphogenesis, wound healing, tissue repair and remodelling in response to injury, e.g. after myocardial infarction, and in progression of diseases such as atheroma, arthritis, cancer and chronic tissue ulcers. They are multi-domain proteins and their activities are regulated by tissue inhibitors of metalloproteinases (TIMPs). This review introduces the members of the MMP family and discusses their domain structure and function, proenyme activation, the mechanism of inhibition by TIMPs and their significance in physiology and pathology.
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