化学
诺氟沙星
枯草芽孢杆菌
苯并噻唑
加替沙星
大肠杆菌
抗菌活性
硝基
铜绿假单胞菌
组合化学
立体化学
抗生素
细菌
有机化学
环丙沙星
生物化学
基因
生物
遗传学
烷基
作者
Prabodh Chander Sharma,Ankit Jain,Mohammad Shahar Yar,Rakesh Pahwa,Jasbir Singh,Preeti Chanalia
标识
DOI:10.1016/j.arabjc.2012.11.002
摘要
A series of novel fluoroquinolone derivatives bearing N-thiomide linkage with 6-substituted-2-aminobenzothiazole substituents at the C-7 position were synthesized to obtain potent analogs active against bacterial strains. Some compounds exhibited excellent antibacterial activity against Staphylococcus auerus, Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa bacterial strains. Among all the synthesized compounds 6-nitro substituted benzothiazole along with norfloxacin (4b) and gatifloxacin (4l) showed MIC 05 μg/ml when tested against S. auerus. Moreover, compounds 4d, 4f and 4l showed superior MIC (15, 10, and 15 μg/ml respectively) against B. subtilis. The results of the present study reveal that the compounds have significant antibacterial potential and are suitable candidates for further exploration.
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