内化
受体
单克隆抗体
低密度脂蛋白受体
抗体
分子生物学
低密度脂蛋白
化学
受体介导的内吞作用
人肝
脂蛋白
生物化学
内吞作用
生物
胆固醇
体外
免疫学
作者
Mariarosaria Santillo,Paolo Mondola,F Santangelo,Anna Belfiore,Idolo Tedesco,Chiara Laezza,Rosalba Cerbone,Adriana Romano,Maurizio Bifulco
出处
期刊:Comparative biochemistry and physiology. B. Comparative biochemistry
[Elsevier]
日期:1992-03-01
卷期号:101 (3): 489-494
标识
DOI:10.1016/0305-0491(92)90032-m
摘要
1. BRL-3A cells possess a specific LDL receptor with an apparent mol. wt of 160,000 that binds, with saturation, both human and rat 125I-LDL. 2. Like human fibroblasts, BRL-3A cells also bind, internalize and degrade 125I-hLDL but to a lesser extent. 3. BRL-3A cells also bind the monoclonal antibody against rat liver LDL receptor P1B3. Moreover the LDL receptor activity increases when cells are preincubated with medium containing 5% of LPDS. 4. As with human (h) fibroblasts, treatment of BRL-3A cells with 10(-7) M insulin enhances binding (30%), internalization (18%) and degradation (20%) of 125I-hLDL.
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