Convenient Synthesis of Functionalized Bis‐ureidopyrimidinones Based on Thiol‐yne Reaction

Abstract The preparation of functionalized bis‐ureidopyrimidinones ( Bis‐UPy ) through the thiol‐yne reaction is described. Various Bis‐UPys with different functional groups were synthesized by using the readily available functionalized alkynes and UPy‐thiol to affirm the simplicity and versatility of the methodology.