干细胞
细胞生物学
蛋白质组学
生物
范围(计算机科学)
再生医学
计算生物学
计算机科学
基因
遗传学
程序设计语言
作者
Manousos Makridakis,Maria G. Roubelakis,Antonia Vlahou
标识
DOI:10.1016/j.bbapap.2013.01.032
摘要
Stem cells have been considered as possible therapeutic vehicles for different health related problems such as cardiovascular and neurodegenerative diseases and cancer. Secreted molecules are key mediators in cell-cell interactions and influence the cross talk with the surrounding tissues. There is strong evidence supporting that crucial cellular functions such as proliferation, differentiation, communication and migration are strictly regulated from the cell secretome. The investigation of stem cell secretome is accumulating continuously increasing interest given the potential use of these cells in regenerative medicine. The scope of the review is to report the main findings from the investigation of stem cell secretome by the use of contemporary proteomics methods and discuss the current status of research in the field. This article is part of a Special Issue entitled: An Updated Secretome.
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