回廊的
爆发
医学
B组
呼吸系统
重症监护
流行病学
A组
病毒
内科学
拉伤
儿科
重症监护室
病毒学
重症监护医学
作者
Caroline Breese Hall,Edward E. Walsh,Kenneth C. Schnabel,Christine Long,Kenneth M. McConnochie,Stephen W. Hildreth,Larry J. Anderson
标识
DOI:10.1093/infdis/162.6.1283
摘要
Over 15 years respiratory syncytial virus (RSV) isolates from 1209 hospitalized and ambulatory children were examined for strain group and in a subset for subgroup to determine the associated epidemiologic and clinical characteristics. Three patterns of yearly outbreaks existed: (1) strong predominance of group A strains (9 years with 83%-100% A strains), (2) relatively equal proportions of group A and B strains (4 years), and (3) strong predominance of group B strains (78%-85%) in 2 years, separated by a decade. The first pattern of highly dominant A strains occurred in cycles of 1 or 2 consecutive years with a single intervening year in which B strains were greater than or equal to 40% of the isolates. Subgroups A1 and A2 predominated, while B2, 3, and 4 occurred almost equally. A greater clinical severity for Group A strains was suggested by children with group A infections requiring intensive care significantly more often (15.4 vs. 8.3%, P = .008). Further, strongly dominant A strain years were associated with higher proportions of RSV admissions requiring intensive care (16.6% vs. 5.5%, P less than .01). Strains of subgroups A2 and B4 were more frequently found in hospitalized patients and A1 in outpatients, and the 2 years with the highest rates of intensive care admissions were those in which subgroup A2 dominated.
科研通智能强力驱动
Strongly Powered by AbleSci AI