瞬时受体电位通道
TRPV公司
TRPC公司
TRPC5公司
细胞生物学
伸展激活离子通道
化学
G蛋白偶联受体
离子通道
生物
生物化学
内向整流钾离子通道
信号转导
受体
TRPV1型
作者
I. Scott Ramsey,Markus Delling,David E. Clapham
出处
期刊:Annual Review of Physiology
[Annual Reviews]
日期:2006-01-01
卷期号:68 (1): 619-647
被引量:1398
标识
DOI:10.1146/annurev.physiol.68.040204.100431
摘要
The aim of this review is to provide a basic framework for understanding the function of mammalian transient receptor potential (TRP) channels, particularly as they have been elucidated in heterologous expression systems. Mammalian TRP channel proteins form six-transmembrane (6-TM) cation-permeable channels that may be grouped into six subfamilies on the basis of amino acid sequence homology (TRPC, TRPV, TRPM, TRPA, TRPP, and TRPML). Selected functional properties of TRP channels from each subfamily are summarized in this review. Although a single defining characteristic of TRP channel function has not yet emerged, TRP channels may be generally described as calcium-permeable cation channels with polymodal activation properties. By integrating multiple concomitant stimuli and coupling their activity to downstream cellular signal amplification via calcium permeation and membrane depolarization, TRP channels appear well adapted to function in cellular sensation. Our review of recent literature implicating TRP channels in neuronal growth cone steering suggests that TRPs may function more widely in cellular guidance and chemotaxis. The TRP channel gene family and its nomenclature, the encoded proteins and alternatively spliced variants, and the rapidly expanding pharmacology of TRP channels are summarized in online supplemental material.
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