载脂蛋白E
等位基因
发病年龄
风险因素
遗传学
退行性疾病
疾病
生物
阿尔茨海默病
医学
内科学
基因
作者
Elizabeth H. Corder,Ann M. Saunders,Warren J. Strittmatter,Donald E. Schmechel,P. C. Gaskell,Gary W. Small,Allen D. Roses,Jonathan L. Haines,Margaret A. Pericak‐Vance
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1993-08-13
卷期号:261 (5123): 921-923
被引量:8122
标识
DOI:10.1126/science.8346443
摘要
The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-epsilon 4 alleles in 42 families with late onset AD. Thus APOE-epsilon 4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-epsilon 4 was virtually sufficient to cause AD by age 80.
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