佐剂
免疫原性
免疫疗法
免疫系统
癌症研究
癌症免疫疗法
粒细胞巨噬细胞集落刺激因子
肿瘤抗原
抗原
细胞因子
医学
癌症疫苗
抗原呈递
免疫学
转移
T细胞
癌症
内科学
作者
Shiying Liu,Wei Wei,Hua Yue,Dezhi Ni,Zhanguo Yue,Shuang Wang,Qiang Fu,Yueqi Wang,Guanghui Ma,Zhiguo Su
出处
期刊:Biomaterials
[Elsevier]
日期:2013-11-01
卷期号:34 (33): 8291-8300
被引量:64
标识
DOI:10.1016/j.biomaterials.2013.07.020
摘要
Whole cell tumor vaccine (WCTV), as a potential treatment modality, elicits limited immune responses because of the poor immunogenicity. To address this issue, researchers have attempted to transduce a cytokine adjuvant into tumor cells, but these single-adjuvant WCTVs curtail the high expectations. In present study, we constructed a multi-adjuvant WCTV based on the nanoparticles modified with cell penetrating peptide, which could facilitate the transportation of granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin 2 (IL-2) into tumor cells. After inactivation, as-designed multi-adjuvant WCTV exhibited programmed promotions on DC recruitment, antigen presentation, and T-cell activation. In vivo evaluations demonstrated the satisfactory effects on tumor growth suppression, metastasis inhibition, and recurrence prevention. Therefore, the nanoparticles-based multi-adjuvant WCTV may serve as a high-performance treatment for anti-tumor immunotherapy.
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