化学
细胞生物学
接吻奔跑融合
小泡
突触囊泡循环
胞吐
突触后密度
活动区
作者
Fabio Benfenati,Flavia Valtorta,Evelina Chieregatti,Paul Greengard
出处
期刊:Neuron
[Elsevier]
日期:1992-02-01
卷期号:8 (2): 377-386
被引量:129
标识
DOI:10.1016/0896-6273(92)90303-u
摘要
Synapsin I is a neuron-specific phosphoprotein that binds to small synaptic vesicles and F-actin in a phosphorylation-dependent fashion. We have found that dephosphorylated synapsin I induces a dose-dependent increase in the number of actin filaments, which at high ionic strength is abolished by synapsin I phosphorylation. The increase in filament number appears to be due to a nucleating effect of synapsin I and not to a barbed-end capping/severing activity. Synaptic vesicle-bound synapsin I was as effective as free synapsin I in increasing the number of filaments. These data support the view that synapsin I is involved in the regulation of the dynamics of the actin-based network during the exo-endocytotic cycle.
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