舍曲林
安慰剂
心理学
随机对照试验
认知行为疗法
临床心理学
精神科
性虐待
5-羟色胺再摄取抑制剂
萧条(经济学)
创伤后应激
创伤应激
医学
毒物控制
认知
内科学
伤害预防
焦虑
抗抑郁药
替代医学
经济
病理
宏观经济学
环境卫生
作者
Judith A. Cohen,Anthony P. Mannarino,James M. Perel,Virginia R. Staron
标识
DOI:10.1097/chi.0b013e3180547105
摘要
Objective To examine the potential benefits of adding a selective serotonin reuptake inhibitor, sertraline, versus placebo, to trauma-focused cognitive-behavioral therapy (TF-CBT) for improving posttraumatic stress disorder and related psychological symptoms in children who have experienced sexual abuse. Method Twenty-four 10- to 17-year-old female children and adolescents and their primary caretakers were randomly assigned to receive TF-CBT + sertraline or TF-CBT + placebo for 12 weeks. Results Both groups experienced significant improvement in posttraumatic stress disorder and other clinical outcomes from pre- to posttreatment with no significant group × time differences between groups except in Child Global Assessment Scale ratings, which favored the TF-CBT + sertraline group. Conclusions Only minimal evidence suggests a benefit to adding sertraline to TF-CBT. A drawback of adding sertraline was determining whether TF-CBT or sertraline caused clinical improvement for children with comorbid depression. Current evidence therefore supports an initial trial of TF-CBT or other evidence-supported psychotherapy for most children with PTSD symptoms before adding medication.
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