石墨烯
抗菌活性
金黄色葡萄球菌
纳米技术
体内
化学
量子点
纳米材料
材料科学
细菌
生物
生物技术
遗传学
作者
Hanjun Sun,Nan Gao,Kai Dong,Jinsong Ren,Xiaogang Qu
出处
期刊:ACS Nano
[American Chemical Society]
日期:2014-06-02
卷期号:8 (6): 6202-6210
被引量:632
摘要
Herein, an antibacterial system combining the “safe” carbon nanomaterials, graphene quantum dots (GQDs), with a low level of H2O2 has been put forward. It has been found that the peroxidase-like activity of GQDs originates from their ability to catalyze the decomposition of H2O2, generating ·OH. Since the ·OH has a higher antibacterial activity, the conversion of H2O2 into ·OH improves the antibacterial performance of H2O2, which makes it possible to avoid the toxicity of H2O2 at high levels in wound disinfection. All the experiments in vitro display that this intrinsic activity exerts a high enhancement of antibacterial activity of H2O2, and the designed system possessed broad spectrum of antibacterial activity against both Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria. More importantly, to assess the antibacterial efficacy of the designed system in actual wound disinfection, the GQD-Band-Aids are prepared and show excellent antibacterial property with the assistance of H2O2 at low dose in vivo.
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