Progress of Transient Receptor Potential(TRP) Channels Related to Mechanosensation

Transient receptor potential (TRP) channels are non-selective cation channels associated with six-transmembrane domains. They are widely distributed in the mammal and crucially involved in the various physiological and pathologic processes,such as noxious stimuli and inflammation. Recently, lots of evidences show that the TRP channels also play important roles in mechanosensation. This review focuses on recent advances of the roles of TRP channels in mechanosensation, especially in auditory function. We also summarize the activation and regulation mechanisms of TRP channels and prospect the future research direction.