Objective To investigate the relationship between perioperative blood transfusion and postoperative wound infection in patients with oral squamous cell carcinoma(OSCC). Methods 753 patients with OSCC in T2 stage were retrospectively analysed. Results Postoperative wound infection rates of patients with perioperative blood transfusion and patients without perioperative blood transfusion were 8.4% and 3.9%,respectively,and there was a significant statistical difference between the two groups (P0.05). Postoperative wound infection rate was increased with the amount of blood transfusion. Conclusion Postoperative wound infection rate of patients with perioperative blood transfusion is significantly higher than that of patients without perioperative blood transfusion. Perioperative blood transfusion should be applied properly.