Effect of Thiopental on Pharmacokinetics of Propofol in Patients Undergoing General Anesthesia

OBJECTIVE To study the effect of thiopental on pharmacokinetics of propofol in patients undergoing general anesthesia.METHODS 16 Patients undergoing general anesthesia were divided into 2 groups randomly.After intravenous administration of propofol 2 mg·kg-1 or 1% propofol and 2.5% thiopental in a ratio of 1:1 volume mixture,the serum concentrations of propofol were measured by high performance liquid chromatography.The pharmacokinetic parameters of propofol were estimated by 3P97 program.RESULTS The serum concentration-time profiles of propofol were discribed by a three compartment model.The pharmacokinetic parameters for two groups were as follows:t1/2α(0.8±0.4) and(0.7±0.3)min,t1/2β(10.2±15.6) and(6.5±5.0) min,t1/2γ(113.0±47.2) and(159.0±82.5) min,Vc(0.055±0.022) and(0.052±0.041) L·kg-1,CL(17.4±4.5) and(15.5±8.3) mL·h-1·kg-1,AUC(108.92±31.68) and(88.84±59.08) mg·min·L-1,respectively.CONCLUSION No significant differences were found among the main pharmacokinetic parameters in two groups,which is in good accordance with that of the literature reports.