Advance in Molecular Mechanism of Infectious Bronchitis Virus Infection

Infection of infectious bronchitis virus(IBV)is seriously harmful to the world poultry industry.IBV in chicken in vivo tissue tropism can be divided into 6 types:respiratory type,kidney type,addicted intestinal type,muscular type,glandular type and fallopian tube type.Pathological lesions of the body′s main organs caused by IBV strains of different tissue tropism have significant differences.What is the molecular mechanism of IBV infection,its tissue and cellular tropism?It is not yet fully understood.In this paper,the brief advance in the relationship of IBV molecular variation and Changes in virulence,receptormediated cell IBV infections and IBV different characteristics due with different types of cells in vitro cultivation,were reviewed to provide a reference for the future research of the molecular mechanism of IBV infection and tissue tropism.