Roles of PTEN in Neuronal Injury and Brain Disorders

Phosphatase and tensin homolog gene(PTEN)was identified as a tumor suppressor located in 10q23 with dual phosphatase activity,its deleted or inactivation often leads to cancer.PTEN express widely in nervous system,which lipid and protein phosphatase activities can regulate neuronal injury and incidence of brain dysfunction through Akt signaling pathway and interaction with the membrane receptor N-methyl-D-aspartate receptor and 5-hydroxytryptamine2c receptor.So,the further study of PTEN will have potential clinical value in the treatment of cancer and neurological diseases.