Effect of Ligustrazini on Rat Small Intestine in Acute Radiation Enteritis

Objective To study the effect of Ligustrazini on the morphology of rat small intestine in acute rediation enteritis Methods Twenty-two SD rats were randomly divided into three groups.To the control group(n=8)and ligustrazini group(n=8)whole abdominal radiation was performed,then physiologic saline and ligustrazini respectively were given peritoneal injection continuously for 7 days.The normal group(n=6)received no irradiation.Other indices were measured by using histochemical analysis,light microscopy and image analysis system.Results The ligustrazini group after radiation had a significant increase in gut protein and DNA content,villus height,crypt depth,the thickness of mucosa and entire wall and number of metaphase mitoses per crypt.Conclusion Ligustrazini can accelerate the healing of the injured small intestinal epithelium,maintain small the normal structure and function of the small intestine.