Injectable in situ Forming Drug Delivery Systems for Protein

The ability to inject a drug incorporated into a polymer to a localized site and in situ to form drug delivery systems has a number of advantages,such as ease of application and location,prolonged drug delivery,and decreased body drug dosage.Recent years,increasing in situ forming drug delivery systems were developed to use in delivering hydrophilic model drugs,especially protein.This article outlined the various strategies used in in situ forming system,including thermoplastic pastes,in situ cross-linking polymer system,In situ polymer precipition,thermally induced gelation.The advantages and disadvantages as localized protein drug candidates were discussed as well.