D301 weakly basic resin was used as an adsorbent for Cr(Ⅵ)adsorption and desorption.The effect of the adsorption time,adsorption tempreture and pH on adsorption capacity were discussed.The adding amount and time of desorption agent on adsorption capacity were analyzed.The experimental results indicated that it facilitated to adsorb for Cr(Ⅵ)in acid medium at pH=2,the equilibrium time of adsorption was achieved within 6 h,the adsorption isotherm could be fitted by the Langmuir equation.The desorption showed better performance with 3% NaOH and desorption time was 30 min,the desorption rate could be reached 97.59%,three times adsorption desorption proved its excellent adsorption for Cr(Ⅵ).