The mononuclear phagocyte system of the mouse as demonstrated by the immunoperoxidase technique using anti-mouse macrophage antiserum.

With an antibody raised to mouse peritoneal macrophages, it is possible to demonstrate macrophages in various murine tissues using an immunoperoxidase technique. The distribution of these cells is described and illustrated. The antigenic determinant(s) appears to reside on the macrophage surface and this has been confirmed by appropriate electron microscopic studies of stained Kupffer cells. With an antibody to human macrophages, the method may be useful in clinical histopathological practice.