Expression and Significance of ADAMTS-4 in Synovial Fluid of Knee Osteoarthritis

Objective To investigate expression and significance of ADAMTS-4 in synovial fluid of knee osteoarthritis.Method Among 87 patients with single-side knee osteoarthritis,45 of them suffered from early-stage knee osteoarthritis,and 42 of them from medium-later-stage knee osteoarthritis.The levels of ADAMTSs in synovial fluid of patitents were determined.30 healthy volunteers were selected into the control group.Results ADAMTSs-4 in synovial fluid had higher expression in the early stage OA group than in the late stage OA group(P0.05).Only a few ADAMTS-4 in synovial fluid were expressed in the control group.Conclusion ADAMTS-4 in synovial fluid have high expression in the early stage and late stage OA groups,and ADAMTS-4 has value in the early diagnosis of OA.