Objective To investigate the clinical efficacy of left-sided hepatolithiasis treated by left hepatic lobe resection combined with choledochoscopic lithotomy. Methods retrospective analysis was conducted on the clinical data of 60 cases of left hepatolithiasis from January 2009 to December 2013. 30 cases undergoing left hepatic lobe resection combined choledochoscope lithotomy were as observation group,while 30 cases receiving left liver resection were as control group. Both groups were compared for intraoperative blood loss,operative time,postoperative complications and short-term efficacy. χ2test or Fisher 's exact test was used for count data,t-test for measurement data,P 0. 05 was considered statistically significant. Results The amount of intraoperative blood loss was(371. 54 ± 167. 65) ml and(508. 97 ± 203. 65) ml respectively in observation group and control group; operation time was(188. 45 ± 39. 76) min and(237. 67 ± 40. 37)min respectively in observation group and control group; the incidence of postoperative complications was 10. 00% and 30. 00% respectively in observation group and control group; intraoperative blood loss,operative time,postoperative complications were significantly lower in observation group than in control group,which showed statistically significant difference(t =-1. 938,t =-2. 127,χ2= 4. 038,P 0. 05). The incidence of postoperative residual stones was 6. 67% and 0% respectively in observation group and control group; and the excellent rate of treatment was 92. 59% and 92. 0% respectively in observation group and control group,there was no statistically significant difference(χ2= 0. 045,0. 023,P 0. 05). Conclusions Left hepatic lobe resection combined with choledochoscope lithotomy for left hepatolithiasis is safe,effective,and worthy of clinical application.