Compare the effectiveness of scintigraphy in technetium-99m-sestamibi with in technetium-99m-peplomycin in patients with benign and malignant lesion in the lung

Objective: To compare the effectiveness of scintigraphy in technetium - 99m - sestamibi (MIBI) with in technetium - 99m -peplomycin(PPM) in patients with benign and malignant lesion in the lung.Methods: The scintigraphy was performed with technetium99m-MIBI in 48 patients and technetium - 99m - PPM in 39 patients with pulmonary lesions .In this study, the imagin results were analyzed and the early and delayed tumor - to - normal lung uptake raio(T/N)were measaured and the retention index(RI) and the delayed uptake index(DUI) were calculated.Then above Parameters were compared between in technetium - 99m - MIBI and in technetium - 99m -PPM. Results: The sensitivity, specificity and accuuacy for technetium - 99m - MIBI scintigraphy were 94. 12%, 85. 71 % and 91. 67%, fortechnetium - 99m - PPM scintigraphy 90. 91 %, 83. 33% and 89. 74%. There was no significant difference in the sensitivity, specificity andaccuracy among the two scintigraphys(P 0. 05). In malignant lesion group, the early T/N, delayed T/N, RI and DUI for technetium -99m - MIBl scintigraphy were 1. 36, 1. 37, 0. 74 and 1. 38, for technetiam - 99m - PPM scintgraphy 1.13, 1. 36, 11. 77 and 1. 64. Therewas no significant difference in the early T/N and delayed T/N among the two scintigraphys(P 0.05) and there was significant low in RI (P 0. 01) and DUI (P 0. 05)for technetium - 99m - MIBI scintigraphy that wer compared with those for technetium - 99m - PPM scintigraphy. In the benign lesion group, there was no significant difference in the early T/N, delayed T/N, RI and DUI between in technetium -99m - MIBI scintigraphy and in technetitun - 99m - PPM scintigraphy(P 0. 05). Conclusions: The both scintgraphys in technetium -99m - MIBl and in technetium - 99m - PPM seem to be good candidaet for noninvasive methods to diagnose pulmonary neoplasm and to distinguish between benign and malignant lesion in the lung.Some lung neoplasm cells extruded more technetium - 99m - MIBI than technetium - 99m - PPM.