Changes of glucocorticoid receptor expression in guinea pig cochlea after acute hypoxia

Objective To observe the changing characteristics of cochlear glucocorticoid receptor(GR) expression after acute hypoxia.Methods GR in the guniea pig cochlea was examined by immunohistochemistry and image analysis system after acute hypoxia.Results GR was stained in the cochlea,especially in the organ of Corti,spiral ligament,stria vascularis and spiral ganglion.The expression of GR was significantly attenuated at each of the above mentioned position after hypoxia and the attenuate at ligament and stria vascularis was more obvious.Conclusion Hypoxia has an obvious inhibiting effect on GR expression in the guniea pig cochlea.GR may be involed in the mechanism of cochlear anoxic injury.