Peripheral nerve injury is still an unsolved problem. The cause, pathology, classification of peripheral nerve injury as well as impact factors on repair of peripheral nerve injury were reviewed in this paper. Primary repair should be done as soon as possible by using microsurgical technique. There should be no tension between two ends of the injured nerve while repairing. If large defect exist, there will be tension between the nerve stumps. Several methods such as changing position of extremity,dissecting two nerve stumps, changing the route of the nerve routine, shortening bone or nerve graft can be used to overcome the large defect of peripheral nerve.