Cationic Glycopolymers with Aggregation-Induced Emission for the Killing, Imaging, and Detection of Bacteria
生物物理学
荧光
糖类聚合物
两亲性
作者
Die Li,Jing Chen,Mei Hong,Yan Wang,David M. Haddleton,Guang-Zhao Li,Qiang Zhang
出处
期刊:Biomacromolecules [American Chemical Society] 日期:2021-04-28卷期号:22 (5): 2224-2232被引量:1
标识
DOI:10.1021/acs.biomac.1c00298
摘要
Cationic glycopolymers with structures similar to those of typical poly(ionic liquid)s (PILs) were synthesized via the quaternization reaction of poly(4-vinyl pyridine) with halogen-functionalized d-mannose and tetraphenylethylene units. Such postpolymerization modification provided PILs with aggregation-induced emission effect as well as specific carbohydrate-protein recognition with lectins such as concanavalin A. The interactions between cationic glycopolymers and different microorganisms, including Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli, were used for the killing, imaging, and detection of bacteria. Besides, these sugar-containing PILs showed a relatively low hemolysis rate due to the presence of saccharide units, which may have potential application in the field of biomaterials.