A new near-infrared excitation PDT photosensitizer in vivo

Recently, near-infrared (NIR) excitation has been suggested for PDT improvement and therapy of cancer.In this study, 5-aminolevulinic acid (ALA), a kind of photosensitizer, were coordinated to CuInS₂/ZnS QDs to form the CuInS₂/ZnS-ALA conjugates. An efficient transfer of energy from the donor (QDs) to the acceptor (ALA) was demonstrated through forster resonance energy transfer (FRET). The treatment effects of the conjugates in vivo was confirmed under 1300nm femtosecond laser. The results demonstrate that the CuInS2/ZnS-ALA conjugates are promising for PDT and can be used in imaging and biomedical field.