磷酸戊糖途径
细胞生物学
柠檬酸循环
粒细胞巨噬细胞集落刺激因子
糖酵解
氧化磷酸化
线粒体
生物
胞浆
新陈代谢
信号转导
磷酸化
生物化学
巨噬细胞
化学
酶
体外
作者
Matthew Wessendarp,Miki Watanabe-Chailland,Serena Liu,Traci E. Stankiewicz,Yan Ma,Rajesh K Kasam,Kenjiro Shima,Claudia Chalk,Brenna Carey,Lindsey-Romick Rosendale,Marie Dominique Filippi,Paritha Arumugam
出处
期刊:Mitochondrion
[Elsevier]
日期:2022-01-01
卷期号:62: 85-101
被引量:23
标识
DOI:10.1016/j.mito.2021.10.009
摘要
Granulocyte-macrophage colony-stimulating factor (GM-CSF) exerts pleiotropic effects on macrophages and is required for self-renewal but the mechanisms responsible are unknown. Using mouse models with disrupted GM-CSF signaling, we show GM-CSF is critical for mitochondrial turnover, functions, and integrity. GM-CSF signaling is essential for fatty acid β-oxidation and markedly increased tricarboxylic acid cycle activity, oxidative phosphorylation, and ATP production. GM-CSF also regulated cytosolic pathways including glycolysis, pentose phosphate pathway, and amino acid synthesis. We conclude that GM-CSF regulates macrophages in part through a critical role in maintaining mitochondria, which are necessary for cellular metabolism as well as proliferation and self-renewal.
科研通智能强力驱动
Strongly Powered by AbleSci AI