N6-甲基腺苷
RNA甲基化
核糖核酸
转录组
非编码RNA
生物
信使核糖核酸
计算生物学
甲基化
长非编码RNA
细胞生物学
生物信息学
基因表达
遗传学
基因
甲基转移酶
作者
Walid Sweaad,Francesca Maria Stefanizzi,Aránzazu Chamorro-Jorganes,Yvan Devaux,Costanza Emanueli
标识
DOI:10.1016/j.yjmcc.2021.05.006
摘要
N6-methyladenosine (m6A) is the most abundant and well-studied internal modification of messenger RNAs among the various RNA modifications in eukaryotic cells. Moreover, it is increasingly recognized to regulate non-coding RNAs. The dynamic and reversible nature of m6A is ensured by the precise and coordinated activity of specific proteins able to insert ("write"), bind ("read") or remove ("erase") the m6A modification from coding and non-coding RNA molecules. Mounting evidence suggests a pivotal role for m6A in prenatal and postnatal development and cardiovascular pathophysiology. In the present review we summarise and discuss the major functions played by m6A RNA methylation and its components particularly referring to the cardiovascular system. We present the methods used to study m6A and the most abundantly methylated RNA molecules. Finally, we highlight the possible involvement of the m6A mark in cardiovascular disease as well as the need for further studies to better describe the mechanisms of action and the potential therapeutic role of this RNA modification.
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