纳米颗粒
材料科学
纳米技术
纳米复合材料
共价键
化学
化学工程
有机化学
工程类
作者
Liang Chen,Wenxing Wang,Jia Tian,Fanxing Bu,Tiancong Zhao,Minchao Liu,Runfeng Lin,Fan Zhang,Myongsoo Lee,Dongyuan Zhao,Xiaomin Li
标识
DOI:10.1038/s41467-021-24838-7
摘要
Abstract The potential applications of covalent organic frameworks (COFs) can be further developed by encapsulating functional nanoparticles within the frameworks. However, the synthesis of monodispersed core@shell structured COF nanocomposites without agglomeration remains a significant challenge. Herein, we present a versatile dual-ligand assistant strategy for interfacial growth of COFs on the functional nanoparticles with abundant physicochemical properties. Regardless of the composition, geometry or surface properties of the core, the obtained core@shell structured nanocomposites with controllable shell-thickness are very uniform without agglomeration. The derived bowl-shape, yolk@shell, core@satellites@shell nanostructures can also be fabricated delicately. As a promising type of photosensitizer for photodynamic therapy (PDT), the porphyrin-based COFs were grown onto upconversion nanoparticles (UCNPs). With the assistance of the near-infrared (NIR) to visible optical property of UCNPs core and the intrinsic porosity of COF shell, the core@shell nanocomposites can be applied as a nanoplatform for NIR-activated PDT with deep tissue penetration and chemotherapeutic drug delivery.
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