医学
前列腺癌
泌尿科
下尿路症状
前列腺
增生
尿酸
国际前列腺症状评分
妇科
内科学
人口
前列腺特异性抗原
前瞻性队列研究
癌症
环境卫生
作者
Soheila Siroosbakht,Sadra Rezakhaniha,Farshad Namdari,Bijan Rezakhaniha
出处
期刊:Andrologia
[Wiley]
日期:2021-08-02
卷期号:53 (10)
被引量:2
摘要
There are conflicting results about uric acid (UA) effect on the prostate. We investigated the relationship between UA and PSA, free PSA, prostate volume and international prostate symptoms score (IPSS) in benign prostate hyperplasia (BPH). This study was conducted in BPH men without cancer who were referred for annual health workup (N = 910) from 2017 to 2020. The mean ages were 67.28 ± 9.2 years. UA was positively related to IPSS and PSA (r = 0.210, p = .023 and r = 0.156, p = .041 respectively) and also negatively related to free/total PSA ratio (r = −0.332, p = .01) but not related to prostate volume (r = 0.036, p = .696). After adjustment for age, BMI and prostate volume, there were significant relationships between hyperuricaemia and PSA, free/total PSA ratio, and IPSS (95% CI: 0.254–1.645, OR = 0.647, p = .039; 95% CI: 0.076–0.899, OR = 0.270, p = .033 and 95% CI: 1.011–3.386, OR = 1.851, p = .038 respectively). These results should be considered during the general assessment of the patients with BPH. The findings raise the possible hypothesis of relationship between serum UA with IPSS and PSA which should be investigated by future studies.
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