Facile synthesis of dendrimer like mesoporous silica nanoparticles to enhance targeted delivery of interleukin-22

Interleukin (IL)-22 is a multifunctional cytokine with a very short half-life that activates STAT3 and can elicit an anti-inflammatory response. We show encapsulation of IL-22 in LPMSN enhances its biological activity and stability in in vitro and human colonic organoids.