光致聚合物
纳米纤维
醋酸纤维素
静电纺丝
药物输送
丙烯酰胺
聚合物
纤维素
高分子化学
材料科学
化学工程
布洛芬
涂层
肿胀 的
控制释放
聚乙烯醇
乙基纤维素
复合材料
单体
纳米技术
工程类
药理学
医学
作者
Mohamed F. Attia,Ahmed S. Montaser,Mohammad Arifuzzaman,Megan Pitz,Khouloud Jlassi,Angela Alexander-Bryant,Stephen S Kelly,Frank Alexis,Daniel C. Whitehead
出处
期刊:Polymers
[MDPI AG]
日期:2021-06-03
卷期号:13 (11): 1863-1863
被引量:12
标识
DOI:10.3390/polym13111863
摘要
In this study we developed electrospun cellulose acetate nanofibers (CANFs) that were loaded with a model non-steroidal anti-inflammatory drug (NSAID) (ibuprofen, Ib) and coated with poly(acrylamide) (poly-AAm) hydrogel polymer using two consecutive steps: an electrospinning process followed by photopolymerization of AAm. Coated and non-coated CANF formulations were characterized by several microscopic and spectroscopic techniques to evaluate their physicochemical properties. An analysis of the kinetic release profile of Ib showed noticeable differences due to the presence or absence of the poly-AAm hydrogel polymer. Poly-AAm coating facilitated a constant release rate of drug as opposed to a more conventional burst release. The non-coated CANFs showed low cumulative drug release concentrations (ca. 35 and 83% at 5 and 10% loading, respectively). Conversely, poly-AAm coated CANFs were found to promote the release of drug (ca. 84 and 99.8% at 5 and 10% loading, respectively). Finally, the CANFs were found to be superbly cytocompatible.
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