Defect‐Engineered Porous C 3 N 4 /CoFe‐LDH Quantum Dot Heterostructures for Synergistic Photocatalytic‐Nanozyme Antibacterial Therapy

ABSTRACT Bacterial infections and the spread of multidrug‐resistant pathogens pose a growing threat to public health as conventional antibiotics lose efficacy, necessitating efficient non‐antibiotic antibacterial strategies. Although ROS‐based photocatalysis and nanozyme catalysis are promising, single‐component systems are often limited by charge‐carrier recombination, low ROS generation efficiency, and slow reaction kinetics. Herein, we report a porous C 3 N 4 @oxygen‐vacancy‐rich CoFe‐LDH quantum‐dot (p‐CN@CF‐O) composite heterostructure, in which ultrasmall CoFe‐LDH quantum dots are uniformly anchored onto the surface of porous C 3 N 4 (p‐CN), forming robust and intimate heterointerfaces. The defect‐rich p‐CN framework facilitates charge transport and reactant adsorption, while oxygen vacancies in the CoFe‐LDH quantum dots markedly enhance peroxidase‐like activity and promote interfacial charge separation. The cooperative effect of multilevel defects significantly boosts ROS generation, enabling highly efficient antibacterial activity under mild conditions. Moreover, the composite serves as a micro‐scaffold that supports epidermal cell proliferation and migration. In a skin infection model in vivo, this material effectively eradicates bacteria, suppresses biofilm formation, and accelerates wound healing, demonstrating outstanding potential for skin anti‐infective therapy. This work not only establishes an efficient photocatalysis‐nanozyme synergistic antibacterial strategy, but also provides valuable insights into the rational design and mechanistic understanding of heterostructured antibacterial materials.