涂层
立方氧化锆
材料科学
软组织
生物医学工程
印章(徽章)
粘附
纳米技术
控制释放
植入
细胞粘附
生物高聚物
成纤维细胞
复合材料
聚酯纤维
组织粘连
硬组织
表面改性
明胶
组织工程
伤口愈合
细胞生长
生物相容性材料
炎症反应
作者
Shu‐di Li,W. Zhao,Yuzhen Huang,Xuan Zhou,Jingyi Ma,Jia‐he Zhu,Jing Qiu
标识
DOI:10.1002/adhm.202505161
摘要
ABSTRACT A stable biological seal is essential for dental implant longevity by preventing peri‐implantitis. Zirconia abutments, though aesthetically pleasing, suffer from a bioinert surface that hinders this seal. Here, we introduce a Sericin@Cu coating that orchestrates a sequential healing cascade, in which the cross‐linked sericin not only provides a stable platform for cell adhesion but also mediates the controlled release of copper ions (Cu 2+ ). Initially, a pH‐responsive release of Cu 2+ provides targeted antibacterial action against early infection. Subsequently, a sustained, low‐concentration release of Cu 2+ promotes angiogenesis, establishing a rich vascular supply that fuels the subsequent stages of soft tissue regeneration. This paves the way for the final stage, where sericin guides fibroblast proliferation and maturation, culminating in a dense, well‐organized fibrous seal. These effects were validated in a rat oral implant model with S. aureus infection, where the coated abutments significantly outperformed controls in establishing a powerful soft tissue barrier. This bio‐inspired coating offers a potent strategy to overcome the limitations of zirconia by actively programming the formation of a robust and lasting peri‐implant seal.
科研通智能强力驱动
Strongly Powered by AbleSci AI