Crucial Role of Trigonal Pyramidal and Rigid Planar Donors in Croconaine Nanoprobe for Tumor NIR-II Fluorescence Imaging and High-Efficiency Phototherapy

generation and a high PCE (82%) under irradiation (808 nm). In preclinical studies, CR-652 NPs exerted synergistic type-I PDT and amplified PTT. Overall, this work offers a promising perspective on the rational design of croconaine-based NIR-II phototheranostic agents for hypoxic-deep tumors by donor-planar and non-planar-engineering.