Emodin induces defensive autophagy against white spot syndrome virus infection via targeting the hemocyanin-mediated endoplasmic reticulum-mitochondrial crosstalk in shrimp

: phosphatidylinositol (4,5)-bisphosphate; RPS6KB1/S6K1: ribosomal protein S6 kinase B1; SDS-PAGE: sodium dodecyl sulfate-polyacrylamide gel electrophoresis; SQSTM1/p62: sequestosome 1; TCA: tricarboxylic acid cycle; TEM: transmission electron microscopy; TFEB: transcription factor EB; UPR: unfolded protein response; VDAC: voltage dependent anion channel; WSSV: white spot syndrome virus; XBP1: X-box binding protein 1.