肝素
荧光
碳水化合物
化学
纳米颗粒
水溶性
氨基葡萄糖
纳米技术
组合化学
有机化学
生物化学
材料科学
量子力学
物理
作者
Yan-Ming Ji,Guang‐jian Liu,Cuiyun Li,Yichen Liu,Min Hou,Guo-wen Xing
标识
DOI:10.1002/asia.201901153
摘要
Two water-soluble carbohydrate-coated AIE-activate fluorescent organic nanoparticles TPE3G and TPE4G were designed and synthesized for the detection of heparin. Different from the reported strategy, we not only utilized the general detection mechanism of electrostatic interactions, but also introduced the concept of carbohydrate-carbohydrate interactions (CCIs) to enrich the detection mechanism of heparin. TPE3G can serve as an efficient “turn-on” probe with higher selectivity towards heparin than TPE4G. TEM studies revealed that the micro-aggregated TPE3G was encapsulated with the heparin chain to form a complex self-assemblied composite and emits strong fluorescence. It is believed that the results illustrated in this study provide a novel strategy based on CCls to design water-soluble and more efficient bio-probes for various biological and clinical applications.
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