分散性
乙二醇
纳米载体
PEG比率
表面改性
药物输送
缺血性中风
材料科学
纳米技术
冲程(发动机)
医学
内科学
化学工程
业务
高分子化学
工程类
缺血
机械工程
财务
作者
Song-Bin Yang,Xiaoliu Li,Kai Li,Xinxin Zhang,Mei Yuan,Yong Guo,Xia Bi
标识
DOI:10.1016/j.nano.2021.102362
摘要
Stroke is one of the most serious problems that seriously affect people's health and brings huge economic burden to society. The development of new nanocarriers with desired degradability and targeted ability is of great significance for efficient drug delivery. In recent years, nano drug delivery system has developed rapidly and applied to treat ischemic stroke. Here, we report the synthesis and functionalization of monodisperse hollow structured MnO2 (H-MnO2). The highly monodisperse H-MnO2 with uniform morphology was obtained by in situ growing MnO2 on solid silica nanoparticles and subsequently removing the silica core. After successive modification of poly ethylene glycol(PEG), we further verified their protective effect on ischemic stroke in our study.
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